Settled by Europeans in the early 19th century, Newtonbrook's early industries included saw and grist mills on the east and west branches of the Don River.
Newtonbrook is most likely best known for being the birth place of Nobel Prize winner and former Prime Minister Lester B. Pearson.
Chinese is the second-most spoken language in the area after English. Korean is well behind as the third. Together they make up over 40% of the ethnic minorities in the area. The area also has significant Russian and Jewish and Iranian minorities.